Endothelial PI 3-kinase activity regulates lymphocyte diapedesis
نویسندگان
چکیده
منابع مشابه
Endothelial PI 3-kinase activity regulates lymphocyte diapedesis.
Lymphocyte recruitment to sites of inflammation involves a bidirectional series of cues between the endothelial cell (EC) and the leukocyte that culminate in lymphocyte migration into the tissue. Remodeling of the EC F-actin cytoskeleton has been observed after leukocyte adhesion, but the signals to the EC remain poorly defined. We studied the dependence of peripheral blood lymphocyte transendo...
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When I was an undergraduate at Caltech, I worked in Bob Edgar’s laboratory on an obscure aspect of phage T4 morphogenesis, which had previously been studied by a little-known South African geneticist, Sydney Brenner [1]. I remember a journal club presented by one of the graduate students in the lab, about the lac repressor binding to DNA. I don’t remember the precise experiments but I know I wa...
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In addition to lipid kinase activity, the class-I PI 3-kinases also function as protein kinases targeting regulatory autophosphorylation sites and exogenous substrates. The latter include a recently identified regulatory phosphorylation of the GM-CSF/IL-3 βc receptor contributing to survival of acute myeloid leukaemia cells. Previous studies suggested differences in the protein kinase activity ...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2007
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00321.2007